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Up to 85% of all strokes are of ischaemic origin and mostly due to blockage of a cerebral artery by a blood clot. After introduction of thrombolytic therapy for the treatment of acute myocardial infarction in the early 1990s, major trials for the evaluation of this new therapeutic approach to ischaemic stroke were initiated. A good overview of thrombolytic therapy treatments is given by the book of Fiebach& Schellinger.

Important aspects in thrombolytic therapy are
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