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| Stroke induces cell channel opening linked to neuron death |
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12 May 2006
Findings from a new study suggest that stroke may cause neuron death, in part, by opening cell channels that lead to a fatal imbalance of intracellular ions.
"These hemichannels represent a new target for stroke interventions," Dr MacVicar said. However, from a therapeutic standpoint, "blocking the hemichannels may be difficult since a similar type of channel is important for heart function."
The group show that ischaemic-like conditions [O(2)/glucose deprivation (OGD)] open hemichannels, or half gap junctions, in neurons. Hemichannel opening was indicated by a large linear current and flux across the membrane of small fluorescent molecules. Single-channel openings of hemichannels (530 picosiemens) were observed in OGD. Both the current and dye flux were blocked by inhibitors of hemichannels. Therefore, hemichannel opening contributes to the profound ionic dysregulation during stroke and may be a ubiquitous component of ischaemic neuronal death.
Dr MacVicar said that his group is now trying to identify and better understand the triggers for hemichannel opening.
Reference:
Science 2006; 312 (5775): 924-927.
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