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| Early CRP predicts mortality in stroke thrombolysis candidates |
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29 May 2006
Post-stroke levels of C-reactive protein (CRP) appear to be a powerful prognostic indicator in patients undergoing tissue plasminogen activator (t-PA) therapy following stroke, Spanish researchers report in the May issue of Stroke.
Follow-up at 3 months showed CRP was higher in the 19 patients who died (0.85 mg/dL) than in survivors (0.53 mg/dL). In the 94 patients with proximal middle cerebral artery occlusions, CRP level was 0.53 mg/dL in survivors and 0.81 mg/dL in the 13 who died. The only baseline mortality predictors were CRP (odds ratio, 8.51) and age (odds ratio, 6.25).
The researchers conclude that CRP on hospital admission predicts mortality among t-PA-treated patients and that very early recanalisation "does not ameliorate the negative prognostic impact of elevated CRP."
Reference:
Stroke 2006; 37 (5): 1205-1210.
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